Antibiotic and Antimicrobial Use in Dental
Practice
Table of Contents:
Quick Cross-Reference Guide
Section 1 General Principles
1. Principles of Antimicrobial Chemotherapy in Dental and Orofacial Infections/Arie
J. van Winkelhoff, Christina M. J. E. Vandenbroucke-Grauls
2. Microbiological Sampling and Sensitivity Testing/Arie J. van Winkelhoff,
Christina M. J. E. Vandenbroucke-Grauls
Section 2 Drugs of Choice
3. Individual Drugs/Mariano Sanz, David Herrera
4. Topical Antimicrobial Agents: General Principles and Individual Drugs/Andrea
Mombelli, Maurizio S. Tonetti
5. Topical and Systemic Antifungal and Antiviral Agents/Jacob Fleischmann
Section 3 Adverse Reactions
6. Allergic and Other Sensitivity Reactions/Larry J. Peterson
7. Adverse Microbiological Effects/Mariano Sanz, David Herrera
Section 4 Clinical Application
8. Antibiotics in Periodontal Therapy/Sebastian G. Ciancio, Arie J. van
Winkelhoff
9. Oral Malodor/Sushma Nachnani
10. Antibiotics in Endodontic Therapy/J. Craig Baumgartner
11. Antibiotics for Oral and Maxillofacial Infections/Larry J. Peterson
12. Pediatric Considerations/Robert Lindemann, Douglas Harrington
13. Chemotherapeutic Agents in Restorative Dentistry/Perry R. Klokkevold
14. Antimicrobials in Implant Dentistry/Thomas Beikler, Thomas F. Flemmig
Section 5 Special Considerations
15. Prophylactic Antibiotic Use/Joan Otomo-Corgel, Stephen T. Sonis
16. Antimicrobial Therapy for Immunocompromised Patients/Joan Otomo-Corgel
17. Considerations for Female Patients/Joan Otomo-Corgel
18. Patients with Common Systemic Diseases/Mark J. Redd, Stefan A. Hienz
19. Legal Considerations/Edwin J. Zinman
Appendixes
Contributors
J. Craig Baumgartner, DDS, MS, PhD, Chairman, Department of Endodontology,
Oregon Health Sciences University, Portland, Oregon
Thomas Beikler, Dr med, Assistant Professor, Clinic of Periodontology, Center
for Dentistry and Oral Medicine, Westfalian-Wilhelms University, Muenster,
Germany
Sebastian G. Ciancio, DDS, Professor and Chair, Department of Periodontics,
Director, Center for Dental Studies, School of Dental Medicine, State University
of New York, Buffalo, New York
Jacob Fleischmann, MD, Professor, Section of Oral Biology and Medicine,
School of Dentistry, University of California at Los Angeles, Los Angeles,
California
Thomas F. Flemmig, Prof Dr med dent, Chairman, Clinic of Periodontology,
Center for Dentistry and Oral Medicine, Westfalian-Wilhelms University,
Muenster, Germany
Larry Peterson, DDS, MS, Clinical Professor, Department of Oral and
Maxillofacial Surgery, Ohio State University, Columbus, Ohio
Douglas Harrington, DDS, Private Practice, Pediatric Dentistry and
Orthodontics, San Diego, California
David Herrera, DDS, Dr Odont, Associate Professor, Faculty of Odontology,
Complutense University of Madrid, Madrid, Spain
Stefan A. Hienz, PhD, DMD, Section of Periodontics, School of Dentistry,
University of California at Los Angeles, Los Angeles, California
Perry R. Klokkevold, DDS, MS, Associate Professor and Clinical Director,
Postgraduate Periodontics and Implant Surgery, School of Dentistry, University
of California at Los Angeles, Los Angeles, California
Robert Lindemann, DDS, MEd, MS, Professor and Associate Dean, School of
Dentistry, University of California at Los Angeles, Los Angeles, California
Andrea Mombelli, DDS, PhD, Professor and Chair, Department of Periodontology
and Oral Pathophysiology, School of Dental Medicine, University of Geneva,
Geneva, Switzerland
Sushma Nachnani, MS, Director, University Health Resources Group, Culver
City, California
Joan Otomo-Corgel, DDS, MPH, Chair of Research, Dental Service, Veterans
Administration Greater Los Angeles Healthcare System, Los Angeles, California;
Adjunct Assistant Professor, Section of Periodontics, School of Dentistry,
University of California at Los Angeles, Los Angeles, California
Mark Redd, DDS, Private Practice, Periodontics and Dental Implants, Laguna
Hill, California
Mariano Sanz, MD, DDS, Vice-Dean, Faculty of Odontology, Complutense
University of Madrid, Madrid, Spain
Stephen T. Sonis, DMD, DMSc, Professor and Chair, Department of Oral Medicine
and Diagnostic Sciences, Harvard School of Dental Medicine, Boston,
Massachusetts; Chief, Division of Oral Medicine, Oral and Maxillofacial Surgery
and Dentistry, Dana-Farber Cancer Institute, Boston, Massachusetts; Senior
Surgeon, Brigham and Women’s Hospital, Boston, Massachusetts
Maurizio S. Tonetti, DMD, PhD, MMSc, Professor and Chair, Department of
Periodontology, Eastman Dental Institute and Hospital, University College
London, London, United Kingdom
Christina M.J.E. Vandenbroucke-Grauls, MD, PhD, Professor, Medical
Microbiology and Infection Prevention, Academic Hospital Vrije University
Amsterdam, Amsterdam, The Netherlands
Arie J. van Winkelhoff, PhD, Professor, Department of Oral Microbiology,
Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
Edwin J. Zinman, DDS, JD, Attorney at Law, San Francisco, California; Former
Lecturer, Department of Periodontology, University of California at San
Francisco, San Francisco, California
Preface
Antibiotics and antimicrobials have become a critical and integral part of
dental practice. Accordingly, there is a growing need for precise strategies and
guidelines governing their use. The new and updated information contained in
this completely revised second edition is essential for every practitioner.
Although modernized in appearance and updated in content, the book remains the
same important reference and resource that has become one of the most popular
books in its field.
This second edition of Antibiotic and Antimicrobial Use in Dental Practice
integrates basic facts and principles with concepts that have emerged during the
last 6 years. As in the previous edition, a group of internationally recognized
experts has been assembled to provide the most direct and pertinent information
for application to clinical practice.
Above all, this book is user-friendly. Useful and informative tables, charts,
algorithms, and information boxes support concise discussions of relevant
information. In addition, icons have been generously dispersed throughout each
chapter to alert the reader to important facts and principles.
A new chapter on general principles describes the infections and
bacteriologically associated complications that can arise in the oral cavity.
These conditions, diseases, and complications are among the most common
situations dealt with in clinical practice. This background serves as the
foundation for many of the systemic and topical agents described in the rest of
the book.
Completely new or expanded chapters on viral and fungal infections, oral
malodor, systemic disease complications, and special considerations for female
patients, as well as a revised chapter on topical agents, offer a comprehensive
view of the proper prescription and use of the bewildering array of agents
currently available. Essential information about new therapies, including a form
of periodontal therapy involving devices that deliver local controlled release
of antimicrobials in the periodontal pocket, are discussed in a straightforward,
practical manner.
Recognizing the integral role implants play in dental practice, specific
guidelines are provided to assist the practitioner in the use of antimicrobials
for the treatment of peri-implant infections as well as in the maintenance and
treatment of plaque-associated conditions. Another chapter addresses the growing
need for awareness of legal issues associated with the use of antibiotics and
antimicrobials in clinical practice. This chapter illustrates the pertinent
medicolegal and ethical issues through real-life examples drawn from cases,
trials, and verdicts.
The chapter on restorative dentistry considerations discusses the mutual
relationship between restorative dentistry and periodontics. This chapter also
provides up-to-date information and suggestions for diagnosing, treating, and
preventing infections in patients with removable prostheses.
Finally, this new edition consolidates the most significant information
discussed in detail in the text in a series of highly useful quick-access
tables, boxes, and charts. A listing of the most useful tables, boxes, and
charts and where they can be found is provided in the Quick Cross-Reference
Guide starting on page xiii.
The editors would like to thank the contributors for their excellent work and
their dedication to improving the lives of patients, who depend on clinicians to
have the most useful and accurate information possible. They also would like to
thank the staff at Quintessence Publishing, whose collaboration and hard work
helped to make this edition a truly comprehensive revision.
REVIEWS
".....Each chapter in the book is concise and the authors cite ample references.
The book makes excellent use of the remarkably superb and informative tables,
charts, algorithms and information boxes. Important areas are highlighted and
icons are dispersed throughout the book to alert the reader to important facts
and principles. The information boxes support concise discussions of relevant
information.
The book starts with a 'quick cross-reference guide' which lists the pages in
the book where information on a given topic has been summarized for easy access.
This is a handy item when one needs to use the book as a quick reference to
treat a certain condition with antibiotic therapy. It is a well-written and
user-friendly text. I plan to use it as a reference book. The general dentist as
well as the specialist will find this book beneficial."
Reviewed by Louis A. Imburgia, DDS, in CDS Review, September 2001
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